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Figure 3: Oral squamous cell carcinoma. (a) Well localized tumor islands, (b) tumor cells invading the surrounding stroma. Immunoperoxidase stain for type IV collagen, hematoxylin counterstain, (a) ×25; (b) ×40. In early carcinomas, tumor islands were localized by continuous deposition of type IV collagen (a), while type IV collagen was disrupted as discontinuous deposition of antibody in later stages of carcinomas (b)

Figure 3: Oral squamous cell carcinoma. (a) Well localized tumor islands, (b) tumor cells invading the surrounding stroma. Immunoperoxidase stain for type IV collagen, hematoxylin counterstain, (a) ×25; (b) ×40. In early carcinomas, tumor islands were localized by continuous deposition of type IV collagen (a), while type IV collagen was disrupted as discontinuous deposition of antibody in later stages of carcinomas (b)