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Figure 2: Oral squamous cell carcinoma. (a) Separated tumor cell nests, (b) packed tumor cell nests. Immunoperoxidase stain for type IV collagen, hematoxylin counterstain, ×25. In the invading front of squamous cell carcinomas, tumor cell nests were surrounded by strong type IV immuno-positive lines (a), while the type IV immunostaining intensity for type IV collagen was weaker in densely packed tumor cell nests in the central part of tumor tissues

Figure 2: Oral squamous cell carcinoma. (a) Separated tumor cell nests, (b) packed tumor cell nests. Immunoperoxidase stain for type IV collagen, hematoxylin counterstain, ×25. In the invading front of squamous cell carcinomas, tumor cell nests were surrounded by strong type IV immuno-positive lines (a), while the type IV immunostaining intensity for type IV collagen was weaker in densely packed tumor cell nests in the central part of tumor tissues