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Figure 2: MPNST with perineurial differentiation. (a) Spindly tumor cells arranged in fascicles and whorls, exhibiting nuclear atypia, mitoses (circle), focal inclusions (thin arrow) and polygonal cells (thick arrow) (H and E, × 200). Inset: Slender tumor nuclei and elongated processes, reminiscent of perineurial differentiation (H and E,× 400). (b) Prominent mitoses (H and E,x400). (c) Focal myxoid degeneration (H and E,× 200). (d) Focal epithelioid differentiation within the tumor adjacent to necrosis (H and E, × 400). Inset: Epithelioid cells (H and E, × 400). (e) Areas of tumor necrosis (H and E, × 200).

Figure 2: MPNST with perineurial differentiation. (a) Spindly tumor cells arranged in fascicles and whorls, exhibiting nuclear atypia, mitoses (circle), focal inclusions (thin arrow) and polygonal cells (thick arrow) (H and E, × 200). Inset: Slender tumor nuclei and elongated processes, reminiscent of perineurial differentiation (H and E,× 400). (b) Prominent mitoses (H and E,x400). (c) Focal myxoid degeneration (H and E,× 200). (d) Focal epithelioid differentiation within the tumor adjacent to necrosis (H and E, × 400). Inset: Epithelioid cells (H and E, × 400). (e) Areas of tumor necrosis (H and E, × 200).