Journal of Cancer Research and Therapeutics

REVIEW ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 3  |  Page : 405--409

Nod-like receptor protein 3 inflammasome in head-and-neck cancer


K Sheeja, S Lakshmi 
 Division of Cancer Research, Regional Cancer Centre, Laboratory of Molecular Medicine, Medical College, Thiruvananthapuram, Kerala, India

Correspondence Address:
K Sheeja
Division of Cancer Research, Regional Cancer Centre, Laboratory of Molecular Medicine, Medical College, Thiruvananthapuram - 695 011, Kerala
India

Activation of inflammasomes has a decisive role in host defense mechanism against pathogens and other intracellular risk factors, but recently, it has been revealed that they play a significant role in the pathogenesis of several diseases, including cancer. Nod-like receptor protein 3 (NLRP3) inflammasome, the best-studied inflammasome, has contrasting roles in cancer development and progressions. In head-and-neck cancers, the upregulated level of NLRP3 promotes tumor progression. The main objective of this review is to provide current knowledge on the involvement of NLRP3 inflammasome in head-and-neck cancers. Deeper understanding of the biology of this dynamic protein complex provides new scope for the development of more effective anticancer therapies.


How to cite this article:
Sheeja K, Lakshmi S. Nod-like receptor protein 3 inflammasome in head-and-neck cancer.J Can Res Ther 2020;16:405-409


How to cite this URL:
Sheeja K, Lakshmi S. Nod-like receptor protein 3 inflammasome in head-and-neck cancer. J Can Res Ther [serial online] 2020 [cited 2020 Aug 7 ];16:405-409
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=3;spage=405;epage=409;aulast=Sheeja;type=0