Journal of Cancer Research and Therapeutics

REVIEW ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 3  |  Page : 401--404

Relevance of serum and salivary sialic acid in oral cancer diagnostics


Victoria Devi Guruaribam, T Sarumathi 
 Department of Oral Medicine Diagnosis and Radiology, Sree Balaji Dental College and Hospital, BIHER, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. T Sarumathi
Department of Oral Medicine Diagnosis and Radiology, Sree Balaji Dental College and Hospital, BIHER, Chennai - 600 100, Tamil Nadu
India

To review the relevance of sialic acid as a tumour marker in oral cancer. Tumour marker are useful in the screening for early malignancy. Sialic acids are important in determining the surface properties of cells and has been implicated in cellular invasiveness, adhesiveness, and immunogenicity. Sialic acids are commonly found at the outermost end of glycan chains of all cell types. Increase in the levels of sialic acid in oral cancer indicates its importance as a tumour marker.Both serum and salivary sialic acid levels can be used as a screening tool and a diagnostic aid for oral cancer. Salivary sialic acid can be used as a non-invasive, cost effective and reliable diagnostic methods for screening and monitoring of oral cancer. In patients with oral cancer, glycoprotein metabolism is altered. Increase in the levels of sialic acid in oral cancer indicate its importance as a tumour marker. Changes in the serum is reflected in saliva. Salivary sialic acid can be used as non-invasive, cost effective and reliable diagnostic methods for screening and monitoring of oral cancer. Early the diagnosis, better the prognosis.


How to cite this article:
Guruaribam VD, Sarumathi T. Relevance of serum and salivary sialic acid in oral cancer diagnostics.J Can Res Ther 2020;16:401-404


How to cite this URL:
Guruaribam VD, Sarumathi T. Relevance of serum and salivary sialic acid in oral cancer diagnostics. J Can Res Ther [serial online] 2020 [cited 2020 Aug 7 ];16:401-404
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=3;spage=401;epage=404;aulast=Guruaribam;type=0