Year : 2019 | Volume
: 15 | Issue : 2 | Page : 317--323
Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma
Yong Guo1, Hai-Cong Zhang2, Sheng Xue3, Jun-Hua Zheng4
1 Department of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing; Transplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2 Department of Pathology, The Fifth Hospital of Shijiazhuang, Shijiazhuang, China
3 Department of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing, China
4 Department of Urology, Shanghai General Hospital of Nanjing Medical University, Nanjing; Department of Urology, The Affiliated First People's Hospital of Shanghai Jiao Tong University, Shanghai, China
Background: The receptor for advanced glycation end-product (RAGE) was one of the signal transduction receptors. RAGE interacted with various signaling molecules which were involved in human disease processes including tumorigenesis. Previous reports have indicated that RAGE/high-mobility group box 1 (HMGB1) could regulate autophagy in different carcinomas. However, the functional role of RAGE/ HMGB1 in the regulation of clear cell renal cell carcinoma (ccRCC) autophagy remained unrevealed.
Methods: Western blot, quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence were used in the present study.
Results: In this study, we demonstrated that the levels of RAGE/HMGB1 and autophagic protein LC3, Beclin-1, PI3K were much higher in ccRCC samples than those of in adjacent normal tissues. RAGE and autophagic protein expression was regulated with RAGE/HMGB1 in human RCC cell lines.
Conclusion: Our results implicated that RAGE and autophagy played important roles in ccRCC, and RAGE/HMGB1 might serve as a novel therapeutic target for future ccRCC treatment.
Dr. Jun-Hua Zheng
No. 101, Longmin Street, Nanjing Medical University, Jiangning, Nanjing 211166
|How to cite this article:|
Guo Y, Zhang HC, Xue S, Zheng JH. Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma.J Can Res Ther 2019;15:317-323
|How to cite this URL:|
Guo Y, Zhang HC, Xue S, Zheng JH. Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma. J Can Res Ther [serial online] 2019 [cited 2019 Nov 12 ];15:317-323
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2019;volume=15;issue=2;spage=317;epage=323;aulast=Guo;type=0