Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 1  |  Page : 231--236

Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model


Hasan Yildiz1, Erkan Kalipci2, Haydar Oztas3, Deniz Yildiz1 
1 Department of Biology, Faculty of Science, Mustafa Kemal University, Antakya, Turkey
2 Department of Environmental Engineering, Faculty of Engineering and Architecture, Nevsehir Haci Bektas Veli University, Nevsehir, Turkey
3 Department of Biology Education, Ahmet Kelesoglu Faculty of Education, Necmettin Erbakan University, Konya, Turkey

Correspondence Address:
Dr. Erkan Kalipci
Department of Environmental Engineering, Faculty of Engineering and Architecture, Nevsehir Haci Bektas Veli University, Nevsehir
Turkey

Aim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. Materials and Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (–SH) content and variations in free and protein-bound molecules containing the –SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period. Results: Changes in the hepatic, pancreatic, and renal –SH contents were also determined. Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound –SH.


How to cite this article:
Yildiz H, Kalipci E, Oztas H, Yildiz D. Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model.J Can Res Ther 2019;15:231-236


How to cite this URL:
Yildiz H, Kalipci E, Oztas H, Yildiz D. Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model. J Can Res Ther [serial online] 2019 [cited 2019 Nov 14 ];15:231-236
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2019;volume=15;issue=1;spage=231;epage=236;aulast=Yildiz;type=0