Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 8  |  Page : 90--96

Circulating gelatinases are not prognostic of treatment response and survival in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy


Sukran Ulger1, Diclehan Kilic1, Fatih Demircioglu2, Canan Y Demirtas3, Ozge T Pasaoglu3 
1 Department of Radiation Oncology, Gazi University Hospital, Ankara, Turkey
2 Department of Radiation Oncology, Kartal Training and Research Hospital, Istanbul, Turkey
3 Department of Biochemistry, Gazi University Hospital, Ankara, Turkey

Correspondence Address:
Sukran Ulger
Department of Radiation Oncology, Gazi University Hospital, 06500 Besevler, Ankara
Turkey

Purpose: To investigate whether the serum levels of matrix metalloproteinases (MMPs) are predictive on treatment response and survival in locally advanced rectal cancer (LARC) patients undergoing preoperative chemoradiotherapy. Patients and Methods: Serum MMP-2 and MMP-9 was analyzed by enzyme-linked immunosorbent assay and obtained before, midway, and 1-month after the end of preoperative radiotherapy treatment. The prognostic significance of serum MMP-2 and MMP-9 levels and their association with other pathological findings for LARC patients were evaluated. Results: Serum levels of MMP-2 or MMP-9 were found to decrease with increasing clinical stage and negative correlation was statistically significant (P < 0.05). There was no statistically significant difference in tumor response and survival between the low and high MMP-2 and MMP-9 groups. MMP-2 and MMP-9 were not correlated with local-regional recurrence. Conclusions: We propose that serum levels of MMP-2 and MMP-9 are not predictive on treatment response and survival in LARC patients.


How to cite this article:
Ulger S, Kilic D, Demircioglu F, Demirtas CY, Pasaoglu OT. Circulating gelatinases are not prognostic of treatment response and survival in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy.J Can Res Ther 2018;14:90-96


How to cite this URL:
Ulger S, Kilic D, Demircioglu F, Demirtas CY, Pasaoglu OT. Circulating gelatinases are not prognostic of treatment response and survival in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy. J Can Res Ther [serial online] 2018 [cited 2019 Jul 16 ];14:90-96
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=8;spage=90;epage=96;aulast=Ulger;type=0