Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 7  |  Page : 1606--1612

Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: A comparison study of HybridKnife-assisted versus conventional dissection technique


Yong-yi Cheng, Yi Sun, Jing Li, Liang Liang, Tie-jun Zou, Wei-xing Qu, Ya-zhuo Jiang, Wei Ren, Chun Du, Shuang-kuan Du, Wen-cai Zhao 
 Department of Urology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China

Correspondence Address:
Yong-yi Cheng
Department of Urology, Shaanxi Provincial People's Hospital, 256 Youyi West Road, Xi'an, Shaanxi
China

Subjects: The aim of this study is to compare the efficacy and safety of en bloc bladder tumor-endoscopic submucosal dissection (BT-ESD) and conventional transurethral resection of BT (TURBT) in nonmuscle invasive bladder cancer (NMIBC) patients. Methods: A retrospective cohort study was carried out in Shaanxi Provincial People's Hospital. A total of 193 eligible NMIBC (Ta/T1) patients were enrolled in this study (95 cases in BT-ESD group and 98 cases in TURBT group), between November 2013 and January 2017. The operation time, blood loss, postoperative bladder irrigation time, catheter indwelling time, hospital stay time, and complications were compared. Data were presented as median (range). Chi-squared or rank-sum test, two-way ANOVA, and Mantel–Cox (Log-Rank) test were performed using statistical software. A threshold of P < 0.05 was defined as statistically significant. Results: The average operation time in the BT-ESD group was longer than that of in the TURBT group (40.0 [5.0, 100.0] min vs. 19.5 [3.0, 55.5] min); however, no significant longer operating time (P < 0.05) were observed in the smaller tumor (0 cm–3 cm). The postoperative bladder irrigation time, catheter indwelling time, and hospital stay in BT-ESD group were significantly shorter than that of in TURBT group (9.0 [5.0, 18.0] h, 2.5 [1.0, 4.0] d and 3.5 [2.0, 5.0] d for BT-ESD; 18.0 [12.0, 48.0] h, 3.5 [2.0, 7.0] d, and 4.5 [3.0, 8.0] d for TURBT). In addition, the BT-ESD group showed the decreased overall incidence of complications (2.1% vs. 9.2%). The univariate and multivariate analyses indicated an association between surgical option and tumor recurrence (hazard ratio = 5.624, odds ratio = 95% confidence interval = 1.582–19.991), Kaplan–Meir analysis showed significant difference in recurrence-free survival (RFS) (94.7% for ESD group vs. 78.4% for TURBT group) at 33 months. Conclusions: The application of the HybridKnife lead to a decrease in complications and RFS rate, which was a more safe and effective approach for NMIBC than conventional TURBT.


How to cite this article:
Cheng Yy, Sun Y, Li J, Liang L, Zou Tj, Qu Wx, Jiang Yz, Ren W, Du C, Du Sk, Zhao Wc. Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: A comparison study of HybridKnife-assisted versus conventional dissection technique.J Can Res Ther 2018;14:1606-1612


How to cite this URL:
Cheng Yy, Sun Y, Li J, Liang L, Zou Tj, Qu Wx, Jiang Yz, Ren W, Du C, Du Sk, Zhao Wc. Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: A comparison study of HybridKnife-assisted versus conventional dissection technique. J Can Res Ther [serial online] 2018 [cited 2020 Jan 29 ];14:1606-1612
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=7;spage=1606;epage=1612;aulast=Cheng;type=0