Journal of Cancer Research and Therapeutics

REVIEW ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 7  |  Page : 1469--1475

Therapeutic approaches targeting cancer stem cells


Yunzhi Pan1, Sai Ma1, Kaiyue Cao2, Sufang Zhou3, Aiqin Zhao3, Ming Li1, Feng Qian1, Chuanwu Zhu1 
1 The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, China
2 Tianjin First Center Hospital, Tianjin, China
3 The People's Hospital of SND, Suzhou, China

Correspondence Address:
Chuanwu Zhu
The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou 215007
China

Increasing studies have demonstrated that most tumors consisted a subpopulation of cells with stem cell properties, known as cancer stem cells (CSCs). Accumulating evidence indicated that CSCs may be critical driving force for several types of cancer. Hence, it was necessary to develop therapeutic approaches specifically targeting CSCs. In this review, first, the biological properties of CSCs were introduced, including the self-renewal and differentiation, high tumorigenesis and invasiveness, resistance to chemotherapy and radiotherapy, genetic and epigenetic variations. Meanwhile, CSCs-targeted therapeutic strategies were summarized, including targeting cell surface markers, signaling pathways, CSC niches, differentiation therapy, and drug resistance for CSCs. Furthermore, clinical trials on anti-CSCs therapies supported the efficacy of these therapies, as well as their combination with conventional chemotherapy and radiotherapy. CSCs could be significantly eradicated, eventually resulting in inhibited tumor growth, metastasis, and recurrence. Thus, selectively targeting CSCs with various agents may be a novel and promising therapeutic strategy against cancer.


How to cite this article:
Pan Y, Ma S, Cao K, Zhou S, Zhao A, Li M, Qian F, Zhu C. Therapeutic approaches targeting cancer stem cells.J Can Res Ther 2018;14:1469-1475


How to cite this URL:
Pan Y, Ma S, Cao K, Zhou S, Zhao A, Li M, Qian F, Zhu C. Therapeutic approaches targeting cancer stem cells. J Can Res Ther [serial online] 2018 [cited 2019 Mar 19 ];14:1469-1475
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=7;spage=1469;epage=1475;aulast=Pan;type=0