Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 12  |  Issue : 2  |  Page : 676--680

Meta-analysis of the relationship between microRNA-499 rs3746444 polymorphism and hepatocellular carcinoma risk in Asians


Weiyu Wang1, Hanlin Qin1, Lei Zhou1, Jinliang Ma2 
1 Department of Radiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China
2 Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China

Correspondence Address:
Jinliang Ma
Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, 17 LuJiang Road, Hefei 230001
China

Objective: Numerous studies have reported the role of microRNA-499 rs3746444 polymorphism with hepatocellular carcinoma. (HCC) risk in Asians, but the specific association is still controversial. Materials and Methods: To derive a more precise estimation of the relationship, a meta-analysis was performed. An electronic search of PubMed database was conducted to select relevant studies. Odds ratios. (ORs) with 95% confidence intervals. (CIs) were estimated to assess the relationship between microRNA-499 rs3746444 polymorphism and HCC risk in Asians. Results: Eight relevant studies including 2196 cases and 2701 controls were included in this meta-analysis. When all the eligible studies were pooled into this meta-analysis, no significant association of HCC risk with microRNA-499 rs3746444 polymorphism was found in Asians (TT vs. CC: OR = 1.00 95% CI = 0.54–1.83; TT vs. TC: OR = 0.89, 95% CI = 0.66–1.20; dominant model: OR = 1.13, 95% CI = 0.81–1.58; recessive model: OR = 0.99, 95% CI = 0.56–1.76). Conclusion: This meta-analysis suggests that the microRNA-499 rs3746444 polymorphism is not contributed to the risk of HCC in Asians. However, more studies should be performed in the future to confirm this association.


How to cite this article:
Wang W, Qin H, Zhou L, Ma J. Meta-analysis of the relationship between microRNA-499 rs3746444 polymorphism and hepatocellular carcinoma risk in Asians.J Can Res Ther 2016;12:676-680


How to cite this URL:
Wang W, Qin H, Zhou L, Ma J. Meta-analysis of the relationship between microRNA-499 rs3746444 polymorphism and hepatocellular carcinoma risk in Asians. J Can Res Ther [serial online] 2016 [cited 2020 Aug 14 ];12:676-680
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2016;volume=12;issue=2;spage=676;epage=680;aulast=Wang;type=0