Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 9  |  Issue : 4  |  Page : 638--643

Efficacy of neoadjuvant chemotherapy in down staging locally advanced pre-menopausal breast cancer in Eastern Nigeria: Is four courses adequate?


Ochonma Amobi Egwuonwu, Stanley Nnamdi Anyanwu, Alexander Maduaburochukwu Nwofor 
 Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria

Correspondence Address:
Ochonma Amobi Egwuonwu
Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi
Nigeria

Context: Breast cancer is the most frequent cancer among women in most part of the world and in Nigeria. Neoadjuvant chemotherapy (NAC) has been demonstrated to be a helpful strategy in the context of locally advanced breast cancer (LABC). Aims: To determine if the use of four courses of doxorubicin based neoadjuvant chemotherapeutic regimen will result in significant primary tumor down-staging. Settings and Design: One year prospective study of premenopausal breast cancer patients presenting to the specialty breast clinic. Methods: The patients were recommended for four courses of doxorubicin based NAC and response assessed using response evaluation criteria in solid tumors (RECIST) methodology. Statistical Analysis Used: Simple frequency and descriptive statistics were used to analyze data using SPSS statistical software. Results: One hundred and fourteen patients presented with breast cancer. Their ages ranged from 26 to 51 years with a mean age of 42.1 years ± 7.7 years. Thirty-one patients completed the four courses of NAC. At the end of NAC, 23 (74.2%) patients had more than 30% reduction in primary tumor size and 8 (25.8%) had no response (NR). The response according to the modified RECIST methodology was 12.9% for a complete clinical response, 61.3% for partial response, and 25.8% for NR. Significant clinical response was seen in 74.2% of patients (P < 0.0001) (one sample t-test). Conclusions: Four courses of antracycline based NAC is effective in premenopausal patients with LABC in our environment


How to cite this article:
Egwuonwu OA, Anyanwu SN, Nwofor AM. Efficacy of neoadjuvant chemotherapy in down staging locally advanced pre-menopausal breast cancer in Eastern Nigeria: Is four courses adequate?.J Can Res Ther 2013;9:638-643


How to cite this URL:
Egwuonwu OA, Anyanwu SN, Nwofor AM. Efficacy of neoadjuvant chemotherapy in down staging locally advanced pre-menopausal breast cancer in Eastern Nigeria: Is four courses adequate?. J Can Res Ther [serial online] 2013 [cited 2020 Apr 6 ];9:638-643
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=4;spage=638;epage=643;aulast=Egwuonwu;type=0