Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 9  |  Issue : 3  |  Page : 387--391

The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma


Ali Tahir1, Abdul Hannan Nagi1, Ehsan Ullah2, Omer Sefvan Janjua3 
1 Department of Morbid Anatomy and Histopathology, University of Health Sciences Lahore, Pakistan
2 Department of Pathology, Quaid-e-Azam Medical College Bahawalpur, Pakistan
3 Department of Oral and Maxillofacial Surgery, Punjab Dental College/Allied Hospital Faisalabad, Pakistan

Correspondence Address:
Ehsan Ullah
Department of Pathology, Quaid-e-Azam Medical College Bahawalpur
Pakistan

Objective: Neo-vascularization is vital for an expansion and metastasis of a tumor and is influenced by a number of mediators. Mast cells are believed to release many pro-angiogenic mediators that may help in tumor expansion and invasion. This study describes the role of mast cells and angiogenesis in oral squamous cell carcinoma (OSCC). Study Design: It was a prospective study in which 37 biopsies of well-differentiated OSCC were obtained. Micro-vessels were stained with cluster of differentiation (CD)-34 and mast cells were counted using the Toluidine blue stain. Results: When compared to normal oral mucosal tissue, it was seen that micro-vessel density and mast cell density indeed increases significantly in squamous cell carcinoma; however, they are not correlated to each other. Conclusion: This study reports that angiogenesis does increase in OSCC and mast cells also invade the peri-tumor tissue, but they are not directly correlated.


How to cite this article:
Tahir A, Nagi AH, Ullah E, Janjua OS. The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma.J Can Res Ther 2013;9:387-391


How to cite this URL:
Tahir A, Nagi AH, Ullah E, Janjua OS. The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma. J Can Res Ther [serial online] 2013 [cited 2020 Sep 19 ];9:387-391
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=3;spage=387;epage=391;aulast=Tahir;type=0