Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 8  |  Issue : 4  |  Page : 586--590

Immunohistochemical correlation of epidermal growth factor receptor and c-erbB-2 with histopathologic grading of mucoepidermoid carcinoma


Monir Moradzadeh Khiavi1, Sepideh Vosoughhosseini1, Shirin Saravani2, Monireh Halimi3 
1 Department of Oral Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Oral Pathology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence Address:
Monir Moradzadeh Khiavi
Department of Oral Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz
Iran

Objective: Mucoepidermoid carcinoma is the most common salivary gland malignancy with highly variable biologic potential that correlates with the histopathologic grade of the tumor. Therefore, identification of the histopathologic grade of the mucoepidermoid carcinoma is very important in the treatment and determination of the final prognosis. The present study was performed to survey immunohistochemically Epidermal Growth Factor ReceptorEGFR and c-erbB-2 expression in different grades of mucoepidermoid carcinoma. Materials and Methods: This retrospective study included 46 formalin-fixed, paraffin-embedded blocks of mucoepidermoid carcinoma. Based on histopathologic parameters, samples were classified into three grades. Then new sections were made and stained by immunohistochemistry (IHC) method for EGFR and c-erbB-2. Finally, EGFR and c-erbB-2 expression and their correlation with histopathologic grading were statistically analyzed by ANOVA. Nineteen samples of normal salivary gland tissue were also chosen as control group. Results: The means of EGFR and c-erbB-2 were 71%, 71%, respectively. Statistically significant correlation was found between EGFR expression and histopathologic grading of mucoepidermoid carcinoma of salivary glands (P < 0.001). There was no statistically significant correlation between histopathologic grading of salivary gland mucoepidermoid carcinoma and c-erbB-2 expression (P = 0.60). Conclusion: There is a parallelism between an increase in EGFR expression and increase in the histopathologic grading of salivary gland mucoepidermoid carcinoma. Therefore, the biologic behavior of salivary gland mucoepidermoid carcinoma can be determined by EGFR expression and it is a useful technique for determination of tumor grades and probably their prognosis.


How to cite this article:
Khiavi MM, Vosoughhosseini S, Saravani S, Halimi M. Immunohistochemical correlation of epidermal growth factor receptor and c-erbB-2 with histopathologic grading of mucoepidermoid carcinoma.J Can Res Ther 2012;8:586-590


How to cite this URL:
Khiavi MM, Vosoughhosseini S, Saravani S, Halimi M. Immunohistochemical correlation of epidermal growth factor receptor and c-erbB-2 with histopathologic grading of mucoepidermoid carcinoma. J Can Res Ther [serial online] 2012 [cited 2020 Jan 27 ];8:586-590
Available from: http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2012;volume=8;issue=4;spage=586;epage=590;aulast=Khiavi;type=0