Journal of Cancer Research and Therapeutics

LETTER TO THE EDITOR
Year
: 2012  |  Volume : 8  |  Issue : 1  |  Page : 159-

Branch chain amino acid supplementation for correction of ascites in liver cancer postembolization


Kamon Chaiyasit1, Viroj Wiwanitkit2,  
1 Mahidol Nutrition Society, Mahidol University, Thailand
2 Visiting Professor, Hainan Medical University, China

Correspondence Address:
Kamon Chaiyasit
Mahidol Nutrition Society, Mahidol University
Thailand




How to cite this article:
Chaiyasit K, Wiwanitkit V. Branch chain amino acid supplementation for correction of ascites in liver cancer postembolization.J Can Res Ther 2012;8:159-159


How to cite this URL:
Chaiyasit K, Wiwanitkit V. Branch chain amino acid supplementation for correction of ascites in liver cancer postembolization. J Can Res Ther [serial online] 2012 [cited 2020 Aug 12 ];8:159-159
Available from: http://www.cancerjournal.net/text.asp?2012/8/1/159/95204


Full Text

Sir,

The use of branch chain amino acid supplementation in cancer is an interesting nutritional management in cancerous patients. [1] Here, the author presents an interesting case study on using of branch chain amino acid supplementation in a case of ascites in liver cancer. This case is a 60-year-old male patient who had the chronic hepatitis B infection and the liver pathology shows liver cirrhosis and hepatocellular carcinoma. He got the previous embolization therapy of liver tumor in the past month. In this case, the patient develops the ascites and consulted to clinical dietitian for correction of ascites. The branch chain amino acid supplementation is given parenteral nutrition high branch chain amino acid formula (peripheral parenteral nutrition) and the regimen is 200 mL drip via intravenous in 1 h (The formula is compose of BCAA 35.5% w/w of total amino acid, amino acid 7.99 w/v, Fisher's ratio 37.05). No other additional pharmacological regimen is given for correction of ascites. Of interest, within 1 week following up, the resolution of the ascites can be derived. Based on this case, the success in using of branch chain amino acid can be derived. Indeed, Takeshita et al. reported that branch chain amino acid help prevent fall in albumin in patients with cirrhosis undergoing embolization for hepatoma. [2] Poon et al. also reported that pretreatment with branch chain amino acid result in significantly lower rate of ascites complication after embolization therapy comparing to no supplementation. [3]

Previously, Okabayashi et al. described that branch chain amino acid supplementation was of clinical benefit about the control of ascites. [4] This case study can further add that using branch chain amino acid as parenteral nutrition can also help correction of ascites in patients with cirrhosis who already got embolization for hepatoma.

References

1Chiarla C, Giovannini I, Boldrini G, Castagneto M. The branched-chain amino acids. Minerva Gastroenterol Dietol 1997;43:189-96.
2Takeshita S, Ichikawa T, Nakao K, Miyaaki H, Shibata H, Matsuzaki T, et al. A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma. Nutr Res 2009;29:89-93.
3Poon RT, Yu WC, Fan ST, Wong J. Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: A randomized trial. Aliment Pharmacol Ther 2004;19:779-88.
4Okabayashi T, Nishimori I, Sugimoto T, Maeda H, Dabanaka K, Onishi S, et al. Effects of branched-chain amino acids-enriched nutrient support for patients undergoing liver resection for hepatocellular carcinoma. J Gastroenterol Hepatol 2008;23:1869-73.