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LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir


1 Human Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India
2 Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India
3 Department of Radiation Oncology, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
4 Department of CVTS, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
5 Department of Surgical Oncology, SMVDNH Superspeciality Hospital, Katra, Jammu and Kashmir, India

Correspondence Address:
Nazir Ahmed Dar,
Department of Biochemistry, University of Kashmir, Srinagar - 180 001, Jammu and Kashmir
India
Swarkar Sharma,
Human Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra - 182 320, Jammu and Kashmir
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_613_19

Background: Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome-wide association study in an Asian population. However, this association has not been replicated in any Indian population despite high incidence of the disease. Materials and Methods: In the present case–control study, 166 cases and 459 controls were included. Taqman assay technique using real-time PCR was employed to investigate the association of the variant with esophageal cancer in the population of Jammu and Kashmir (J&K). The Hardy-Weinberg equilibrium for rs2494938 was assessed using the Chi-square test. The allele- and genotype-specific risk was estimated by odds ratio (OR) with 95% confidence interval (CI). Results: Variant rs2494938 was observed to be significantly associated with esophageal cancer with an allelic OR of 1.59 (1.23–2.04 at 95% CI, P = 0.0003). Conclusion: The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India.


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