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Prevalence of human papillomavirus type 16 in Sudanese women diagnosed with cervical carcinoma

1 Department of Zoology, University of Khartoum, Khartoum, Sudan
2 Department of Public Health, Communicable Diseases Control Programs, Ministry of Public Health, Doha, Qatar
3 Department of Virology, Central Laboratory, Ministry of Higher Education and Scientific Research, Khartoum, Sudan

Correspondence Address:
Elmoubasher Abu Baker Abd Farag,
Department of Public Health, Communicable Diseases Control Programs, Ministry of Public Health, P. O. Box: 42, Doha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_656_18

Objectives: Squamous cell carcinoma (SCC) of the cervix is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HR-HPV) is the major risk factor to develop malignant lesions HR types (HPV16 and HPV18) account for about 70% of all invasive cervical cancers worldwide. It is estimated that 833 Sudanese women are diagnosed with cervical cancer and 534 die from the disease every year. The present study aimed to detect HPV 16, and determine the association of HPV16 with age and various grades of cervical carcinoma in patients with clinically confirmed cervical SCC. Materials and Methods: A total of 158 formalin fixed paraffin embedded tissues blocks from Sudanese women diagnosed as cervical cancer and benign were collected between 2012 and 2016 at Omdurman Maternity Hospital and National Laboratories, Khartoum, Sudan. HPV DNA detection was done using HPV 16 specific primers in real-time polymerase chain reaction. Results: The frequency of HPV 16 was identified among 10.34% (n = 6) and 6% (n= 6) women with abnormal cytology and normal cytology, respectively. Based on age, high prevalence rate of HPV 16 was observed among age group 61–70 in women with malignant cases. The degree of differentiation, an important classification in SCC cases revealed that 5% = 3) cases had moderately differentiated SCC and two of them were keratinized SCC. In addition, 3.4% (n = 2) SCC cases were keratinized and well differentiated. Conclusion: Overall, the prevalence of HPV types 16 was higher but had no significant association with cervical SCC in Sudanese women.

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