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Genetic and proteomic biomarkers of head-and-neck cancer: A systematic review


1 Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania
2 Department of Dental and Oral Diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania
3 Department of Biomedical and Dental Sciences, School of Dentistry, University of Messina, Messina, Italy

Correspondence Address:
Marco Cicciù,
Department of Biomedical and Dental Sciences, School of Dentistry, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Messina
Italy
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_145_17

Development of human genetic and proteomic research has increased the interest in alternative head-and-neck cancer (HNC) detection methods. The aim of this article, the second of two-part series, was to review the scientific literature about novel HNC genetic and proteomic biomarkers. A comprehensive review of the current literature was conducted according to the Preferred Reporting Item for Systematic Review and Meta-analyses guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in English language published from 2004 to 2015. A total of 50 relevant studies were included in the review. Thirty of them concerned proteomic and twenty genetic alterations in HNC. The present systematic review discovered 242 genes and 44 proteins associated with HNC. Due to inconsistent and sparse results, novel biomarkers cannot be firmly established. Prognostic capacity of genetic markers was not evaluated. Proteins (14-3-3γ, extracellular matrix metalloproteinase inducer, and PA28γ) were described as most valuable for prognostic observation of HNC. A strict methodological protocol for molecular studies must be established.


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    -  Kasradze D
    -  Juodzbalys G
    -  Guobis Z
    -  Gervickas A
    -  Cicciù M
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