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A rare case of cerebral hemorrhage associated with intra-arterial infusion chemotherapy for advanced sphenoid sinus cancer
Joichi Heianna1, Yukashi Yamashita2, Yuko Iraha1, Sadayuki Murayama1
1 Department of Radiology, University of the Ryukyus Graduate School of Medical Science, Okinawa, Japan
2 Department of Otorhinolaryngology, University of the Ryukyus Graduate School of Medical Science, Okinawa, Japan
Correspondence Address:
Joichi Heianna,
Department of Radiology, University of the Ryukyus Graduate School of Medical Science, 207, Uehara, Nishihira-Cho, Okinawa
Japan
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jcrt.JCRT_1444_16
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Central nervous damage related to intra-arterial infusion chemotherapy (IAC) for head and neck cancer reported to date are cerebral infarction, transient ischemic attack, and neuropathy. There have been no reports of cerebral hemorrhage as an IAC-related complication for head and neck cancer. Authors report a case that underwent intra-arterial infusion chemoradiotherapy for advanced sphenoid sinus cancer which extended to the left cavernous sinus and cranium, subsequently suffered cerebral hemorrhage thought to have been caused by IAC. Treatment should be performed with greater caution when the head and neck cancer involves the cavernous sinus or cranium, as in the present case.
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