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Drug-induced infiltrative lung disease with weekly paclitaxel in breast cancer: Case series


 Department of Medical Oncology, Apollo Hospitals Bangalore, Bengaluru, Karnataka, India

Correspondence Address:
Renu Raghupathi,
Department of Medical Oncology, Apollo Hospitals, 154/11, Opp IIM Bannerghatta Road, Bangalore - 560 076, Karnataka
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_1225_16

Drug-induced infiltrative lung disease (DI-ILD) can be caused by chemotherapeutic agents, antibiotics, antiarrhythmic drugs, and immunosuppressive agents. Common chemotherapeutic drugs causing DI-ILD include bleomycin, mitomycin C, bis (2-chloroethyl)-l-nitrosourea, cyclophosphamide, busulfan, and methotrexate. Taxanes and trastuzumab are also associated with lung injury. Estimated incidence of paclitaxel-induced lung injury is 0.73%–12%. Although cases of paclitaxel-induced lung injury have been reported previously, we found only one published case report of fatal lung injury caused by paclitaxel use. We are reporting the largest case series of seven patients who developed paclitaxel-induced lung injury along with review of literature.


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    -  Raghupathi R
    -  Patil C
    -  Dhiman P
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