|LETTER TO THE EDITOR
|Ahead of print publication
Helicobacter pylori infection and pancreatic cancer
Amin Talebi Bezmin Abadi
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Amin Talebi Bezmin Abadi,
Department of Bacteriology, Tarbiat Modares University, P. O. Box: 14115-111, Tehran
Source of Support: None, Conflict of Interest: None
Guo et al. recently published an interesting meta-analysis entitled Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis in the Journal of Cancer Research and Therapeutics.
However, in part, successful H. pylori gastric colonization was found associated with an occurrence of pancreatic cancer, but in the rest, epidemiological conflicting results hampered concluding statements.
Guo et al. analyzed studies published in databases including MEDLINE, PubMed, Web of Science, and CNKI investigating the association between H. pylori infection and pancreatic cancer risk into an updated meta-analysis. In the following paragraph, we describe some constructive points to enrich the current study as novel findings in this research area.
- Although it happened in many of meta-analysis, the possibility of publication bias should be taken into account before further analysis
- The results raise following this study may be generalized in the case of more consistent reports from various regions of the world
- In-depth studies with larger sample sizes investigating proposed association are needed to validate Guo et al. conclusion. Meanwhile, contributing pathways and potential underlying mechanisms are necessary to be elucidated
- To date, no study has been found confirmed the results by DNA-based tests for H. pylori among suspected subjects. This stone-hacked data can increase the validity for reported analysis.
To our knowledge, pancreatic cancer is one of the leading causes of cancer-related deaths which attracted many attentions recently. Taking together, better study design in close future can provide increased understanding about his mysterious diseases.
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Conflicts of interest
There are no conflicts of interest.
| > References|| |
Guo Y, Liu W, Wu J. Helicobacter pylori
infection and pancreatic cancer risk: A meta-analysis. J Cancer Res Ther 2016;12:C229-32.
Trikudanathan G, Philip A, Dasanu CA, Baker WL. Association between helicobacter pylori
infection and pancreatic cancer. A cumulative meta-analysis. JOP 2011;12:26-31.