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miR-146a is deregulated in gastric cancer


1 Department of Microbiology, Faculty of Biological Science, Islamic Azad University, Falavarjan Branch, Isfahan, Iran
2 Department of Microbiology, Faculty of Biological Science, Islamic Azad University, Falavarjan Branch, Isfahan, Iran; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
3 Department of Biology, Division of Cellular and Molecular Biology, Faculty of Sciences, University of Isfahan; Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
4 Department of Pathology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
5 Zist-Fanavari Novin Biotechnology Institute, Isfahan, Iran

Correspondence Address:
Kamran Ghaedi,
Department of Biology, Division of Cellular and Molecular Biology, Faculty of Sciences, University of Isfahan, Isfahan 81746-73441
Iran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_855_17

 > Abstract 


Background: Gastric cancer is one of the most significant reasons for cancer-related death. miR-146a is one of the dysregulated factors associated with gastric tumorigenesis. However, deregulation of this microRNA (miRNA) has become controversial. Moreover, the inflammation-mediating role of this miRNA implies that miR-146a might be dysregulated by gastric cancer-related pathogens, such as Helicobacter pylori. However, the dysregulation of miR-146a in H. pylori-infected gastric tumors has not been widely studied.
Objectives: We aimed to analyze the expression level of miR-146a in gastric cancer tissues and then to assess any potential association between miR-146a and H. pylori infection and other clinical characteristics.
Materials and Methods: miR-146a expression level was quantitatively studied by reverse transcription quantitative polymerase chain reaction, in 144 fresh tissues including 44 normal and 100 gastric cancer samples.
Results: A dramatic overexpression of miR-146a was observed in primary gastric tumors. miR-146a showed lower expression in progressed tumors with greater stages and lymph node metastasis.
Conclusion: miR-146a is highly expressed in primary gastric tumor independent of H. pylori infection. It is highly expressed in the lower stages and lymph node-negative tumors. It might suggest the importance of upregulation and downregulation of this miRNA in the initiating/promoting and progressive steps of gastric tumorigenesis, respectively.

Keywords: Gastric cancer, Helicobacter pylori, miR-146a, reverse transcription quantitative polymerase chain reaction



How to cite this URL:
Adami B, Tabatabaeian H, Ghaedi K, Talebi A, Azadeh M, Dehdashtian E. miR-146a is deregulated in gastric cancer. J Can Res Ther [Epub ahead of print] [cited 2019 Jan 20]. Available from: http://www.cancerjournal.net/preprintarticle.asp?id=244479

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