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Intraoperative radiotherapy with electrons as partial breast irradiation in limited stage breast cancer: Early term clinical and cosmetic outcomes


1 Department of Radiation Oncology, Gaziosmanpasa University, Tokat, Turkey
2 Department of Radiation Oncology, Ankara Memorial Hospital, Ankara, Turkey
3 Department of Radiation Oncology, Ankara Oncology Hospital, Ankara, Turkey
4 Department of Surgery, Ankara Oncology Hospital, Ankara, Turkey

Correspondence Address:
Gülhan Güler Avci,
Department of Radiation Oncology, Gaziosmanpasa University, Tokat
Turkey
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_191_17

 > Abstract 


Purpose: We aimed to report the experience of intraoperative electron radiation therapy (IOERT) with Mobetron (Intraop Medical Incorporated, Santa Clara, CA, USA) as a partial breast irradiation (PBI) for patients with early-stage breast cancer and explanation of IOERT application and present early clinical and cosmetic result.
Materials and Methods: Between November 2012 and February 2014, in Ankara Oncology Hospital, Radiation Oncology Clinic, was performed IOERT as a PBI with a single dose of 21 Gy for 21selected patients. Median tumor size was 1.5 cm (range, 0.6–2.8 cm). Median treatment duration was 2.04 min (range, 1.26–2.44 min). According to final pathology, two patients were found to have close margin and mastectomy was applied. Three cases (two were N1 mic and one case had perineural invasion and tumor size was >2 cm) received whole breast irradiation.
Results: Median follow-up time was 3 years (range, 26–42 months). One patient died because of nonbreast cancer reason, all of the other patients (except one) alive without disease. There was no Grade 3 or 4 toxicities related to the IOERT. Good or excellent cosmesis was revealed 79% (15/19) and 95% (18/19), by physician and patient, respectively.
Conclusion: IOERT, for patients with early-stage breast cancer as a part of breast-conserving treatment, offer patients better cosmetic results with less skin toxicity and increases comfort of patients by shortening duration of treatment time.

Keywords: Cosmesis, intraoperative radiotherapy, partial breast irradiation, toxicity



How to cite this URL:
Avci GG, Güney Y, Küçükpilakci B, Çalikoğlu T, Gülçelik MA, Özaslan C. Intraoperative radiotherapy with electrons as partial breast irradiation in limited stage breast cancer: Early term clinical and cosmetic outcomes. J Can Res Ther [Epub ahead of print] [cited 2019 May 25]. Available from: http://www.cancerjournal.net/preprintarticle.asp?id=244441

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    -  Gülçelik MA
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