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Effect of Au-197 nanoparticles along with Sm-153 radiopharmaceutical in prostate cancer from simulation method


1 Faculty of Engineering, University of Kyrenia, Girne, North Cyprus, Mersin 10, Turkey; Reactor Research School, Nuclear Science and Technology Institute (NSTRI), Tehran, Iran
2 Department of Electrical and Electronic Engineering, Near East University, Nicosia, North Cyprus, Mersin 10, Turkey
3 Reactor Research School, Nuclear Science and Technology Institute (NSTRI), Tehran, Iran

Correspondence Address:
Akbar Abbasi,
University of Kyrenia, Kyrenia, North Cyprus, Mersin 10

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_183_17

 > Abstract 


Aims: Based on recent studies, it was indicated that gold (Au-197) nanoparticles could be safely prescribed and used to enhance the absorbed dose during radiation therapy.
Subjects and Methods: We evaluated the samarium-153 (Sm-153) radiopharmaceutical and Au-197 and Sm-153 radiopharmaceutical absorbed dose rate by means of the Monte Carlo technique in prostate cancer.
Results: The results show that absorbed dose rate in entire prostate volume due to 20 mCi of Sm-153 radiopharmaceutical is 27.339 μGy/s, 48.837 μGy/s, and 76.176 μGy/s for γ-interaction, β particle interaction, and γ+β interaction, respectively. The results in the exterior of the prostate for β interaction, β particle interaction, and γ+β interaction were 20.971 μGy/s, 1.110 μGy/s, and 22.081 μGy/s, respectively.
Conclusions: The calculation results for Au-197 and Sm-153 radiopharmaceutical show that the absorbed dose rate in entire prostate volume 3% was increased and undesirable dose value in exterior of prostate 7% was decreased.

Keywords: Absorbed dose, MCNP4C, prostate, radiotherapy, samarium-153



How to cite this URL:
Abbasi A, Sadikoglu F, Hassanzadeh M. Effect of Au-197 nanoparticles along with Sm-153 radiopharmaceutical in prostate cancer from simulation method. J Can Res Ther [Epub ahead of print] [cited 2019 Jan 21]. Available from: http://www.cancerjournal.net/preprintarticle.asp?id=244440

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