Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Survival of familial adenomatous polyposis coexistence colorectal cancer in Iran


1 Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Center of Excellent for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Correspondence Address:
Mohammad Hossein Somi,
Golgasht St., Imam Reza Hospital, Tabriz
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_421_17

Context: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder. Colorectal cancer (CRC) has been implicated as the most common cause of death in FAP patients, especially in those with coexisting CRC at initial diagnosis (FAP-CRC). Aim: We aimed to determine the survival rate of FAP-CRC and the factors affecting FAP-CRC survival. Setting and Design: This was a retrospective cohort FAP study conducted in northwest Iran. Subjects and Methods: From 2006 to 2016, 51 FAP-CRC individuals were selected from among 4588 CRC patients. Statistical Analysis: A Student's t-test, life table method, log-rank tests, a Kaplan–Maier survival curve, and Cox regression analysis were performed and a value of P < 0.05 was set as statistically significant. Results: A total of 51 FAP-CRC patients were selected, (30 males and 21 females), with a mean age of 42.2 years at diagnosis. The most common presenting symptom was abdominal pain and the most common primary tumor site was the rectum. The 1-, 5- and 10-year overall survival rates were 76%, 59%, and 52%, respectively. Factors affecting the FAP-CRC survival rate, namely, sex, age at CRC diagnosis, and extracolonic manifestations showed no significant differences. The difference in 5-year survival rates between patients with colon and rectal cancers was significant (75% vs. 33%, P < 0.02). The survival rate was significantly higher among patients with disease Stages I and II than those in disease Stages III and IV (P < 0.001). 5-year survival rates in patients with ileal pouch-anal anastomosis and ileorectal anastomosis were 71% and 78%, respectively (P < 0.001). There was an interesting difference in survival between FAP and attenuated FAP (P < 0.01). In cox regression analysis, distant metastasis was a significant predictor of survival (P < 0.001). Conclusions: Long-term survival from FAP-CRC remains poor; therefore, early-stage detection and the choice of an appropriate surgical method can improve survival in such patients.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Mirinezhad SK
    -  Moaddab SY
    -  Bonyadi MJ
    -  Shirmohammadi M
    -  Eftekharsadat AT
    -  Somi MH
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed154    
    PDF Downloaded3    

Recommend this journal