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Osteoclastic variant of anaplastic thyroid carcinoma: A case report of rare entity

 Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Divya Shelly,
Department of Pathology, Armed Forces Medical College, Sholapur Road, Pune - 411 040, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_355_16

Anaplastic thyroid carcinoma (ATC) is a rare, highly malignant thyroid tumor with dismal prognosis. Osteoclastic giant cell variant of ATC is extremely rare and is characterized by the presence of a large number of multinucleated giant cells resembling osteoclasts. We report here this unusual variant in a 67-year-old female with a history of long-standing goiter of 13 years duration. Histologically, many multinucleated osteoclast-like giant cells were seen accompanying the malignant spindle cell component. Despite extensive sampling, no evidence of differentiated thyroid malignancy could be elucidated.

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