Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

The analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological results


1 Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
2 Department of Pharmacology and Toxicology, Veterinary medicine, Atatürk University, Erzurum, Turkey
3 Department of Medical Services and Techniques, Vocational School of Health Services, Bayburt University, Bayburt, Turkey
4 Department of Pathology, Faculty of Medicine, Atatürk University, Erzurum, Turkey

Correspondence Address:
Maryam Mohammadzadeh,
Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, Erzurum
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_1455_16

Background and Objective: Metformin (MET) has been used as an antidiabetic agent for type II diabetes. At the same time, recent researches have shown that the clinical improvement of MET is useful for nerve damage. In this study, we investigated the analgesic effect of MET in paclitaxel (PAC)-induced neuropathic pain. Materials and Methods: Forty-two adult, female rats, Wistar strain weighing 220 ± 10 g were randomly divided into 5 experimental groups. PAC was intraperitoneally (IP) administered (2.0 mg/kg) for 4 groups every other day (0, 2, 4, and 6 days). By the 30th day, MET (100, 200, and 400 mg/kg) was administered to 4 groups. Before and after treatment, basal pain threshold values were measured with Randall–Selitto analgesiometer test. At the end of experiment, pathological values were measured in selected regions including brain (motor cortex, M1), spinal cord (L4-L5), sciatic nerve, and muscle. Results: According to our results, PAC-induced neuropathic pain reached to highest level at 14th day. Four hundred milligram/kilogram concentration of MET remarkably decreased PAC-induced neuropathic pain. On the other hand, pathologic features have shown that PAC had significant pathological change in the brain and spinal cord while in the peripheral nerves and muscles had not shown any pathological change. Conclusion: The pathological results of the current study for the first time demonstrated that MET beside of its antidiabetic effects reversed neuropathic pain induced by PAC. Consequently, this research can be promising for cancer patients that suffering from neuropathic pain induced by anticancer drugs.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Hacimuftuoglu A
    -  Mohammadzadeh M
    -  Taghizadehghalehjoughi A
    -  Taspinar N
    -  Togar B
    -  Nalcı KA
    -  Okkay U
    -  Gundogdu B
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed498    
    PDF Downloaded22    

Recommend this journal