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Favorable results of patients with pT1a, b, c, lymph node-negative early breast cancer in the long interval


1 Department of Medical Oncology, Kanuni Sultan Suleyman Education and Search Hospital, Turkey
2 Department of Medical Oncology, Ataturk Education and Search Hospital, Ankara, Turkey
3 MKA Clinic Center, Tepe Prime, Ankara, Turkey

Correspondence Address:
Nilufer Bulut,
Department of Medical Oncology, Kanuni Sultan Suleyman Education and Search Hospital,34313, Istanbul
Turkey
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_1275_16

Background: The clinical characteristics of patients who had lymph node-negative early breast cancer were assessed. Patients and Methods: We assessed a total of 576 patients in the study, including 74 patients (12.8%) with T1a, 119 patients (20.7%) T1b, and 367 patients (63.7%) with T1c. Patients with T1 tumors were further classified into three groups according to hormone receptor (HR) and human epidermal growth factor-receptor 2 (HER2) status. Results: In patients with T1a, the disease-free survival (DFS) rate was 98.4% at 2 years (P = 0.001). In subgroup analysis of early breast cancers, 10-year-DFS rates of the patients in HR+/HER2–, HR–/HER2+, and HR–/HER2– subgroups were not significantly different (P = 0.917). Conclusion: The T1a group had a worse prognosis than T1b and T1c groups in second years (P = 0.001); however, there was not statistically important difference between HR+, HER2+ and triple negative subgroups (P = 0.917). Although there are differences in patients and tumor features, the prognosis of patients with T1a, b, c N0M0 breast cancer is excellent.


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    -  Ulas A
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