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Association of vascular endothelial growth factor + 405G>C, − 460C>T gene polymorphism and lung cancer risk


 Department of Respiratory Medicine, The Eighth People's Hospital of Guangzhou, Guangzhou, Guangdong, China

Correspondence Address:
Xiao-Neng Mo,
Department of Respiratory Medicine, The Eighth People's Hospital of Guangzhou, Guangzhou, Guangdong
China
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Source of Support: None, Conflict of Interest: None

Aim of Study: The conclusion of the relationship between vascular endothelial growth factor (VEGF) +405G>C, − 460C>T gene polymorphism and lung cancer risk was inconsistent. This study was performed to assess the relationship between VEGF +405G>C, − 460C>T gene polymorphism and lung cancer risk using meta-analysis. Materials and Methods: The association studies were identified from PubMed and China Biological Medicine Database, and eligible studies were included and calculated. Results: VEGF +405G>C gene polymorphism was associated with lung cancer risk for overall populations in this meta-analysis (C allele: odds ratio [OR] =1.19, 95% confidence interval [CI]: 1.05–1.35, P = 0.008; CC genotype: OR = 1.21, 95% CI: 1.06–1.39, P = 0.006; GG genotype: OR = 0.76, 95% CI: 0.59–0.98, P = 0.04). Furthermore, this relationship was also found in Asian population. However, VEGF − 460C>T gene polymorphism was not associated with lung cancer risk for overall populations and for Asians in this meta-analysis. Conclusion: VEGF +405G>C gene polymorphism was associated with lung cancer risk in overall populations and Asians. However, more studies should be performed to assess this relationship in future.


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    -  Mo XN
    -  Peng P
    -  Zhang WX
    -  Wu PL
    -  Zhou YM
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