|Ahead of print publication
Evaluation and identification of factors related to KRAS and BRAF gene mutations in colorectal cancer: A meta-analysis
Li Lin1, Guang-yong Chen2, Chun-wei Xu3, Hai-yan Wang3, Yong-Fang Wu3, Mei-yu Fang4
1 Department of Gastrointestinal Oncology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, Beijing, China
2 Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
3 Department of Pathology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, Beijing, China
4 Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, China
Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, No. 38 Guangji Road, Gongshu District, Hangzhou, Zhejiang 310022
Source of Support: None, Conflict of Interest: None
Objective: The aim of this meta-analysis is the distribution pattern of KRAS and BRAF mutations in colorectal cancer (CRC).
Materials and Methods: The database was searched without language restrictions. Meta-analyses were conducted using the Stata software. We calculated the odds ratio (OR) and its 95% confidence interval to estimate the distribution of and correlation between KRAS and BRAF mutations, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) in the left- and right-sided CRC.
Results: The studies were divided into five groups: (1) Distribution of KRAS/BRAF mutations in distal and proximal CRCs, the summary OR value was 1.24 versus 4.03, (2) distribution of KRAS/BRAF mutations in CIMP-low/negative and CIMP-high (CIMP-H) tumors, the summary OR value was 0.77 versus 10.49, (3) distribution of KRAS/BRAF mutations in MSI-low (MSI-L)/microsatellite stable (MSS) and MSI-high (MSI-H) tumors, the summary OR value was 0.51 versus 9.60, (4) proportion of CIMP-H/MSI-H tumors among distal and proximal colorectal tumors, the summary OR value was 3.66 versus 6.54, and (5) proportion of CIMP-H tumors among MSI-L/MSS and MSI-H tumors, the summary OR value was 5.87.
Conclusion: The meta-analysis reveals that KRAS has a slightly higher mutation rate in MSI-L/MSS tumors. Moreover, BRAF mutations have a higher detection rates in the right-sided CRC, which suggests that BRAF mutations are likely in CIMP-H tumors. Therefore, based on these findings, the molecular diagnostic tests to be conducted in CRC patients can be determined according to the location/clinical features of the tumor.
Keywords: BRAF gene, colorectal, CpG island methylator phenotype, KRAS gene, microsatellite instability, mutation, tumor
|How to cite this URL:|
Lin L, Chen Gy, Xu Cw, Wang Hy, Wu YF, Fang My. Evaluation and identification of factors related to KRAS and BRAF gene mutations in colorectal cancer: A meta-analysis. J Can Res Ther [Epub ahead of print] [cited 2019 Jul 20]. Available from: http://www.cancerjournal.net/preprintarticle.asp?id=206304
Retraction notice is published as under:
This has been retracted because it was republished in error due to technical reasons.