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Association of cytotoxic T-lymphocyte antigen-4 + 49A/G gene polymorphism with hepatocellular carcinoma risk in Chinese

 Department of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China

Correspondence Address:
Zhiyong Dong,
Department of Surgery, The First Affiliated Hospital of Jinan University, No.613, Huangpu Avenue West, Guangzhou 510630
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.203604

Aim of Study: Hepatocellular carcinoma (HCC), a common cause of cancer-associated mortalities worldwide, is a complex polygenic disease, and its development is dependent on many genetic factors. Hepatitis B virus infection, also called chronic hepatitis B (CHB), is the leading cause of HCC. This meta-analysis was performed to assess the association between cytotoxic T-lymphocyte antigen-4 (CTLA4) +49A/G and HCC risk. Materials and Methods: The association studies were recruited from PubMed and China Biological Medicine Database, and eligible studies were included and synthesized using meta-analysis method. Results: Four reports were included into this meta-analysis for the association of CTLA4 A/G gene polymorphism and HCC risk, and all the included studies were from Chinese. The association between CTLA4 A/G gene polymorphism and HCC risk was found in this meta-analysis (G allele: odds ratio [OR] =1.21, 95% confidence interval [CI]: 1.03–1.44, P = 0.02; GG genotype: OR = 1.21, 95% CI: 1.03–1.44, P = 0.02; AA genotype: OR = 1.37, 95% CI: 1.10–1.69, P = 0.004). Furthermore, G allele and GG genotype were associated with the CHB patients developing into HCC (G allele: OR = 0.81, 95% CI: 0.66–0.98, P = 0.03; GG genotype: OR = 0.75, 95% CI: 0.57–0.99, P = 0.04). Conclusion: CTLA4 A/G gene polymorphism was associated with HCC risk and CTLA4 G allele/GG genotype is associated with CHB patients developing into HCC in Chinese.

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