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Concurrent computed tomography-guided radioactive iodine-125 seeds percutaneous interstitial implantation and chemotherapy for treatment of cervical lymph node metastases


1 Department of Radiology, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo, China
2 Department of Nuclear Medicine, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo, China
3 Department of Oncology, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo, China
4 Department of Urinary Surgery, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo, China
5 Department of Neurology, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo, China

Correspondence Address:
Xiangjie Qi,
Department of Urinary Surgery, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo 255400
China
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Source of Support: None, Conflict of Interest: None

Aim: The study aimed to evaluate the effect of concurrent computed tomography (CT)-guided percutaneous interstitial implantation of iodine-125 (125 I) seeds and chemotherapy on cervical lymph nodes metastasis. Methods: The prospective randomized study included 82 cases with cervical lymph nodes metastasis who were admitted to our hospital from January 2010 to June 2012. All the subjects were randomly divided into the concurrent 125 I implantation and chemotherapy group (n = 48) and chemotherapy-only group (n = 34) according to the treatment strategy. The concurrent 125 I implantation and chemotherapy group was treated with CT-guided 125 I seeds implantation and routine chemotherapy. The routine chemotherapy included paclitaxel and cisplatin. Patients were followed up for 6 months. Results: In the concurrent 125 I implantation and chemotherapy group, overall response rate (complete response [CR] + partial response [PR]) was 82.61% and 85.51% at 2 and 6 months posttreatment, respectively. The longest diameter of CR and PR lymph nodes was markedly decreased after treatment (P < 0.05). In the chemotherapy-only group, overall response rate was 22.45% and 10.20% at 2 and 6 months posttreatment, respectively. The number of patients with moderate to severe pain was much less in concurrent 125 I implantation and chemotherapy group than that of chemotherapy-only group (4.17% vs. 17.64%; P < 0.05) at 6-month posttreatment. No treatment-related death or severe complication was reported in the two groups. Conclusion: Concurrent CT-guided 125 I seeds implantation and chemotherapy is superior to routine chemotherapy in efficacy, safety, and pain relief in patients with cervical lymph nodes metastasis.


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    -  Wang X
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