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Association between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer


1 Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra, Malaysia
2 Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Malaysia
3 Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra, Malaysia
4 Department of Pathology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
5 Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra ; Institute of Bioscience, Universiti Putra , Selangor, Malaysia

Correspondence Address:
Heng Fong Seow,
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor
Malaysia
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Source of Support: None, Conflict of Interest: None

Background: Interleukin (IL)-17A and IL-17F are inflammatory cytokines mainly produced by T helper 17 cells. IL-17A is known to be protumorigenic while IL-17F has a protective role in cancer. A number of studies have been conducted to determine the association between polymorphisms of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) and risk of cancers. No studies have yet to be conducted to genotype the IL-17A G197A polymorphism in colorectal cancer (CRC). Objective: To assess the association of IL-17A G197A and IL-17F A7488G polymorphisms with CRC risk. Materials and Methods: We performed the genotyping by polymerase chain reaction-restriction fragment length polymorphism method on blood samples from 80 healthy individuals and paraffin-embedded tumor tissues from 70 CRC patients. Results: Our study showed that IL-17A 197AA genotype was significantly associated with an increased CRC risk with odds ratios of 6.08 (95% confidence interval [CI]: 2.25–16.42, P < 0.001) and 2.80 (95% CI: 1.23–6.35, P = 0.014), in comparison with GG and AG genotypes, respectively. However, IL-17F A7488G polymorphism was not significantly associated with CRC risk (P = 0.102). No significant association of IL-17A G197A and IL-17F A7488G polymorphisms with patient and tumor variables was found. Conclusion: This report from Malaysia shows the relationship of IL-17A 197AA genotype with susceptibility to CRC.


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