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Neurofibromatosis and breast cancer: Do we need to revise the mammographic screening schedule in patients of neurofibromatosis?


1 Department of Pathology, PGIMER, Chandigarh, India
2 Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India
3 Department of Pediatrics, Grant Medical College, Mumbai, Maharashtra, India
4 Department of Pediatrics, Pt. JNM Medical College, Raipur, Chhattisgarh, India
5 Department of Pathology, Pushpanjali Crosslay Hospital, New Delhi, India
6 Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Correspondence Address:
Dinesh Pradhan,
PGIMER, Sector 12, Chandigarh
India
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Source of Support: None, Conflict of Interest: None

Neurofibromatosis type 1 (NF-1) is a neurocutaneous syndrome with autosomal dominant mode of inheritance and has a high propensity to develop benign and malignant nervous system tumors. Although uncommon, case reports describing the association of NF-1 and breast cancer are available in the literature. We illustrate one such case of NF-1, with no family history of the disorder and presenting with multifocal invasive carcinoma of the right breast, in an attempt to describe the association between these two entities. We also attempt to extensively review the current literature on the subject. Since patients with NF-1 are at an increased risk of developing breast cancer, we recommend strict adherence to careful clinical breast examination and annual screening mammographic examination starting at 40 years of age in all patients of NF-1.


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