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PTEN and SHIP: Impact on lymphatic metastasis in breast cancer


1 Department of General Surgery, Hebei Yanda Hospital, Hebei, China
2 Department of General Surgery, Affliated Hospital of Taishan Medical University, Tai'an, China
3 Department of Gastroenterology, The Army General Hospital, Beijing, China
4 Department of Breast Surgery, Affliated Hospital of Taishan Medical University, Tai'an, China

Date of Web Publication11-Nov-2016

Correspondence Address:
Xiang-qi Li,
Department of Breast Surgery, Affliated Hospital of Taishan Medical University, Tai'an 271000
China
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Source of Support: None, Conflict of Interest: None

 > Abstract 

Lymph node metastasis is the most common form of metastasis in breast cancer and a crucial indicator influencing breast cancer treatment results. The biological process of lymph node metastasis involves deficiency and mutation of tumor suppressor genes. PTEN and SHIP are critical indicators used to detect occurrence, development, invasion, and metastasis of breast cancer. Loss of expressions of PTEN and SHIP may contribute to lymphatic metastasis of breast cancer, so they can be used as objective indicators for judging the biological behavior of breast cancer. In this study, we perform a comprehensive analysis to investigate the effect of PTEN and SHIP gene expression on regulating lymph node metastasis in breast cancer.

Keywords: Breast cancer, gene expression, lymphatic metastasis, PTEN, SHIP



How to cite this URL:
Li K, Li Gd, Sun Ly, Li Xq. PTEN and SHIP: Impact on lymphatic metastasis in breast cancer. J Can Res Ther [Epub ahead of print] [cited 2017 Apr 26]. Available from: http://www.cancerjournal.net/preprintarticle.asp?id=193894

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