Nueclear Web Banner
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

The impact of perioperative blood transfusion on survival and recurrence after radical prostatectomy for prostate cancer: A systematic review and meta-analysis


1 Department of Blood Transfusion, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510150, China
2 Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410000, China

Correspondence Address:
Ye Hanshen,
Department of Blood Transfusion, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510150
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Objective: Conflicting data have been reported regarding the association between perioperative blood transfusion (PBT) and clinical outcomes for prostate cancer patients. We conducted a systematic review and meta-analysis to evaluate the impact of PBT on cancer survival and recurrence for patients who underwent radical prostatectomy (RP). Methods: A systematic review of PubMed, EMBASE, and Cochrane libraries was performed to identify all eligible studies that evaluate the association between PBT and clinical outcomes for prostate cancer patients undergoing RP. The analyzed outcomes were overall survival (OS) and recurrence-free survival (RFS) at 3, 5, and 10 years. Results: A total of eight articles met our criteria. Meta-analysis indicated that prostate cancer patients with PBT had decreased OS (hazard ratio [HR] =1.51, 95% confidence interval [CI], 1.22–1.85, P < 0.01; HR = 1.57, 95% CI, 1.33–1.85, P < 0.01; HR = 1.55, 95% CI, 1.03–2.33, P = 0.04) and RFS (HR = 1.67, 95% CI, 1.37–2.04, P < 0.01; HR = 1.42, 95% CI, 1.23–1.63, P < 0.01; HR = 1.37, 95% CI, 1.03–1.83, P = 0.03) at 3, 5, and 10 years after surgery compared with those without PBT. Conclusions: The findings from the current meta-analysis demonstrate that PBT was associated with adverse survival and recurrence outcomes for prostate cancer patients undergoing RP.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Pushan Z
    -  Manbiao C
    -  Sulai L
    -  Jun L
    -  Ruidong Z
    -  Hanshen Y
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed145    
    PDF Downloaded4    

Recommend this journal