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Symptomatic treatment of brain metastases in renal cell carcinoma with sorafenib


 Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan 250012, China

Correspondence Address:
Xiuwen Wang,
Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan 250012
China
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Source of Support: None, Conflict of Interest: None

Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Further, withdrawal of sorafenib resulted in psychiatric changes along with increased metastasis lesions, which were recovered upon resuming the treatment, proposing that oral sorafenib can be used safely and efficiently for treatment of brain metastasis in advanced RCC.


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    -  Hu D
    -  Hu Y
    -  Li J
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