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Catechol-O-methyltransferase 158G/A polymorphism and endometriosis/adenomyosis susceptibility: A meta-analysis in the Chinese population


1 Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071; Department of Clinical Laboratory, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
2 Department of Clinical Laboratory, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
3 Department of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
4 Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071, China

Correspondence Address:
Yong-yi Bi,
Department of Occupational and Environmental Health, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071
China
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Source of Support: None, Conflict of Interest: None

Purpose: An association between catechol-O-methyltransferase (COMT) 158G/A polymorphism and endometriosis/adenomyosis susceptibility has been reported in the previous studies, but the results were inconsistent. This study was conducted to explore this association in the Chinese population using meta-analysis. Materials and Methods: PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine were searched for all relevant studies published up to December 2015. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations. Results: A total of 7 case–control studies including 782 cases and 700 controls were included in this meta-analysis. Overall, COMT 158G/A polymorphism was found to be significantly associated with endometriosis and adenomyosis risk in the Chinese population (A vs. G, OR = 1.21, 95% CI: 1.02–1.42; AA vs. GG, OR = 1.47, 95% CI: 1.01–2.14; AA vs. GG + GA, OR = 1.42, 95% CI: 0.99–2.03; AA + GA vs. GG, OR = 1.20, 95% CI: 0.97–1.49). In subgroup analyses stratified by ethnicity, source of controls and disease groups, the significant risk was found in Chinese not mentioned the ethnicity, in population-based studies and adenomyosis. Conclusions: COMT 158G/A polymorphism may contribute to the risk of endometriosis and adenomyosis in Chinese, particularly for adenomyosis.


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