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Evaluation of the use of nab-paclitaxel and gemcitabine in clinical practice


 Hospital Pharmacy Service, Estructura Organizativa de Gestión Integrada de Vigo - Hospital, Álvaro Cunqueiro, Vigo, Pontevedra, Spain

Correspondence Address:
Cristina Casanova-Martínez,
Camiño dos Cañotais 44, 36212 Vigo, Pontevedra
Spain
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Source of Support: None, Conflict of Interest: None

Context: Pancreatic cancer in a common tumor in our country for which there are various treatment alternatives. Objective: Evaluate the effectiveness and safety of nab-paclitaxel and gemcitabine in everyday clinical practice. Settings and Design: Observational, retrospective study at a tertiary university hospital. Subjects and Methods: We included patients diagnosed of metastatic or locally advanced pancreatic cancer that were being treated with nab-paclitaxel and gemcitabine. We recorded response, progression-free survival (PFS), and overall survival (OS) rates together with toxicities. Statistical Analysis Used: We used SPSS program for Windows. We conducted descriptive statistics using averages, medians, standard deviations or ranges, and percentages. Results: We included 15 patients. At 3 months, there were no complete responses; 20% showed partial responses, and in 60% of patients, the disease stabilized. The median PFS was 8.9 months and the OS was 9.6. The most important adverse reactions were neutropenia, fatigue, and nausea/vomiting. Conclusions: The treatment regimen leads to increased survival in these patients with an acceptable toxicity profile.


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    -  Casanova-Martínez C
    -  Romero-Ventosa EY
    -  González-Costas S
    -  Arroyo-Conde C
    -  Piñeiro-Corrales G
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