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Associations of interleukin-10 gene polymorphisms with acute myeloid leukemia in human (Egypt)


1 Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt
2 Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt

Correspondence Address:
Hanan E Shafik,
Department of Medical Oncology, National Cancer Institute, Fom El Khalig Sq., Cairo
Egypt
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Source of Support: None, Conflict of Interest: None

Background: Acute myeloid leukemia (AML) is a cytogenetically and molecularly heterogeneous diseases, and characterization of transforming genetic events is becoming increasingly important. Interleukins (ILs) are a diverse set of small cell signaling protein molecules. Single nucleotide polymorphisms (SNPs) of ILs alter their function, increasing susceptibility to different diseases. Patients and Methods: We investigated the association between polymorphism in IL-10 -819T/C (rs1800871) and the risk of AML in the Egyptian population. DNA was isolated from bone marrow of 80 newly diagnosed adult AML patients, and 85 age- and sex-matched controls. Genetic analysis of IL-10 SNPs at -819T/C was assayed by polymerase chain reaction-restriction fragment length polymorphism. Results: Genetic analysis of IL-10 revealed that the Egyptians have high -819T allele frequencies in apparently healthy controls, whereas -819CC genotype and the -819C allele frequencies in the AML group were higher than in the controls (P = 0.000086). The study suggested that subjects carrying the rs1800871CC genotype and C allele had a significantly increased risk for AML. Conclusion: IL-10 SNP at -819 was associated with enhanced AML risk, suggesting that rs1800871 provides clue for future studies and early detection of AML.


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    -  Shafik RE
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