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Survivin expression as an independent predictor of overall survival in pancreatic adenocarcinoma


1 2nd Department of Surgery, Aretaieio University Hospital, National and Kapodistrian University of Athens, Athens, Greece
2 Department of Pathology, Aretaieio University Hospital, National and Kapodistrian University of Athens, Athens, Greece

Correspondence Address:
Panagis M Lykoudis,
2nd Department of Surgery, Aretaieio University Hospital, 75, Vas. Sofias Ave., Athens, 11528
Greece
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Source of Support: None, Conflict of Interest: None

Context: Survivin is an antiapoptotic protein with a role in tumorigenesis and suggested prognostic value in several proliferative diseases. Aims: This study aimed to examine the role of survivin as a prognostic marker in pancreatic adenocarcinoma (PDAC). Settings and Design: Fifty-one specimens of PDAC were assessed for survivin expression by immunohistochemistry. Subjects and Methods: Overall survival and 1-, 3-, and 5-year survival were retrieved retrospectively. Statistical Analysis Used: Bivariate analysis was conducted using Chi-square and Mann-Whitney U tests, while survival analysis was conducted using Kaplan-Meier statistics. Results: Of the 51 assessed cases, 49% were positive for survivin. Survivin expression was significantly correlated 1-year survival and overall survival, particularly in bcl-2 positive cases. Conclusions: Survivin may be implicated in the bcl-2 and p53 pathways and therefore in the biology of PDAC. Its potential use as a survival predictor and therapeutic target represent a promising field.


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    -  Contis J
    -  Lykoudis PM
    -  Goula K
    -  Karandrea D
    -  Kondi-Pafiti A
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