Genetic variants in the microRNA machinery gene (Dicer) have a prognostic value in the management of endometrial cancer
Muhammed Oz1, Savas Karakus1, Malik Yildirim2, Binnur Bagci3, Ismail Sari4, Gokhan Bagci2, Caglar Yildiz1, Ozlem Akkar1, Ali Cetin1, Ali Yanik1
1 Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
2 Department of Medical Genetics, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
3 Department of Nutrition and Dietetics, Cumhuriyet University School of Health Sciences, 58140 Sivas, Turkey
4 Department of Biochemistry, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas
Source of Support: None, Conflict of Interest: None
Aim: Although several associations were found between Dicer rs3742330 single nucleotide polymorphism (SNP) and development and prognosis of some epithelial cancers, relationship between the SNP rs3742330 and endometrial cancer (EC) has not yet been studied. We aimed to investigate the prognostic role of rs3742330 SNP of Dicer gene in EC patients.
Subjects and Methods: A total of 80 EC patients and 80 control subjects included in the study. Real-time polymerase chain reaction and the allele discrimination technique was used for genotyping of rs3742330 SNP.
Results: There was no significant difference between EC patients and control subjects with regard to the genotype and allele frequencies for Dicer rs3742330 SNP (P > 0.05). Despite Dicer rs3742330 SNP had no prognostic value in terms of stage, grade, lymphovascular invasion, myometrial invasion, tumor size, and histopathology; malignant peritoneal cytology has been detected higher in the patients bearing AA genotype compare with AG genotype (P = 0.023). Higher recurrence rate and shorter time to recurrence were found in patients bearing AG and GG genotype compare with AA genotype (P = 0.009).
Conclusion: Dicer rs3742330 AG and GG genotypes may have the potential to be used as a predictor of poor prognosis in the management of EC case.