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Evaluation of boron neutron capture therapy in-phantom parameters by response matrix method

1 Department of Reactor, Nuclear Science and Technology Research Institute, Tehran, Iran
2 Department of Physics, K. N. Toosi University of Technology, Tehran, Iran

Correspondence Address:
Yaser Kasesaz,
Nuclear Science and Technology Research Institute, Tehran
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Source of Support: None, Conflict of Interest: None

Aim: Determination of boron neutron capture therapy in-phantom parameters by response matrix (RM) method. Materials and Methods: In this study, various in-phantom figures-of-merit including therapeutic gain, advantage depth dose rate, advantage depth, therapeutic depth, treatment time, skin dose rate, and skull dose rate have been analyzed using the RM method. This method is based on the division of neutron/gamma spectrum and calculation of various dose components of each energy group. Summation of these dose responses is equal to the total dose of the whole spectrum. Based on this method, in-phantom parameters could be calculated by a computer program in a very short time. Results: There is a good agreement between direct calculation and RM method. The maximum allowable contaminations of the thermal and fast neutrons in a neutron beam have been calculated by RM method. It was found that these values are 17.4% and 2.6%, for thermal and fast neutron, respectively. Conclusion: The results confirm that the RM method is a fast method to evaluate in-phantom parameters without repeating simulations due to change in neutron spectrum and treatment conditions.

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