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Pelvic radiotherapy does not deteriorate the quality of life of women with gynecologic cancers in long-term follow-up: A 2 years prospective single-center study

1 Department of Radiation Oncology, Selcuk University, Konya, Turkey
2 Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey
3 Department of Obstetrics and Gynecology, Selcuk University, Konya, Turkey
4 Department of Pathology, Selcuk University, Konya, Turkey
5 Department of Medical Oncology, Selcuk University, Konya, Turkey
6 Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey

Correspondence Address:
Nasuh Utku Dogan,
Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Antalya
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Source of Support: None, Conflict of Interest: None

Purpose: To evaluate the emotional, sexual and health-related quality of life (HRQoL) concerns of the women with gynecologic malignancy treated with curative radiotherapy (RT). Patients and Methods: A 100 women with diagnosis of gynecologic malignancy were prospectively enrolled. HRQoL at baseline, at the end of RT and during follow-up was assessed using European Organization for Research and Treatment of Cancer QoL Questionnaire-C30 (EORTC QLQ-C30), EORTC QLQ-cervical cancer module 24, and Hospital Anxiety and Depression Scale. Results: The appetite loss, diarrhea, fatigue, dyspnea, insomnia, nausea and vomiting, pain scores, and sexual activity and sexual enjoyment scores were deteriorated after RT (P = 0.02 for pain scores and P < 0.001 for all other). Body image scores were higher in patients with endometrial cancer (P < 0.01). The emotional function, nausea and vomiting, body image and symptom experience scores were higher in patients who underwent chemotherapy (P = 0.04 and P = 0.01). All the complaints of patients improved during follow-up period. The global health status scores and the level of depression deteriorated in patients with locoregional recurrent disease and distant metastasis. The anxiety (P = 0.001) and depression (P = 0.007) levels were higher in basal and after-RT visits but then decreased through the subsequent follow-up visits. Conclusion: Although pelvic RT deteriorated HRQoL in patients with gynecologic malignancy, HRQoL improved during the follow-up period. The progressive disease had a negative impact on HRQoL.

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