Nueclear Web Banner
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Ahead of Print

Clinical efficiency of repeated pulmonary metastasectomy in sarcoma patients with recurrent pulmonary metastasis: A meta-analysis

1 Department of Orthopedics, West Hospital, Sichuan University, Chengdu, China
2 Cancer Center, West Hospital, Sichuan University, Chengdu, China

Correspondence Address:
Chongqi Tu,
Department of Orthopedics, West China Hospital, Sichuan University, Guoxuexiang No. 37, Chengdu 610041
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Introduction: Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results. Materials and Methods: Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library. All eligible articles were included according to inclusion criteria. Then, a meta-analysis was conducted to clarify the clinical efficiency of RPM. Results: A total of 9 articles with 464 patients were included. We found that sarcoma patients with recurrent pulmonary metastasis that underwent RPM had significantly better overall survival (hazard ratio = 0.59; 95% confidence interval, 0.44–0.81; P = 0.001). No significant publication bias was found. Sensitivity analysis showed the results were stable. Conclusion: Selected sarcoma patients with recurrent pulmonary metastasis following the first pulmonary metastasectomy could still benefit from RPM, despite its unfavorable aspects.

Print this article
  Search Pubmed for
    -  Li Y
    -  Zhang W
    -  Li S
    -  Tu C
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded27    

Recommend this journal