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Clinical efficiency of repeated pulmonary metastasectomy in sarcoma patients with recurrent pulmonary metastasis: A meta-analysis


1 Department of Orthopedics, West Hospital, Sichuan University, Chengdu, China
2 Cancer Center, West Hospital, Sichuan University, Chengdu, China

Correspondence Address:
Chongqi Tu,
Department of Orthopedics, West China Hospital, Sichuan University, Guoxuexiang No. 37, Chengdu 610041
China
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Source of Support: None, Conflict of Interest: None

Introduction: Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results. Materials and Methods: Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library. All eligible articles were included according to inclusion criteria. Then, a meta-analysis was conducted to clarify the clinical efficiency of RPM. Results: A total of 9 articles with 464 patients were included. We found that sarcoma patients with recurrent pulmonary metastasis that underwent RPM had significantly better overall survival (hazard ratio = 0.59; 95% confidence interval, 0.44–0.81; P = 0.001). No significant publication bias was found. Sensitivity analysis showed the results were stable. Conclusion: Selected sarcoma patients with recurrent pulmonary metastasis following the first pulmonary metastasectomy could still benefit from RPM, despite its unfavorable aspects.


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    -  Li Y
    -  Zhang W
    -  Li S
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