Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Clinical research of goal-directed fluid therapy in elderly patients with radical resection of bladder cancer


1 Department of Anesthesia, The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei, P.R. China
2 Department of Urology Surgery, The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei, P.R. China
3 Department of Critical Care Medicine, The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei, P.R. China
4 Department of Respiratory Medicine, The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei, P.R. China

Correspondence Address:
Shu_Bo Zhang,
Department of Anesthesia, The Affiliated Hospital of North China University of Science and Technology, No. 73, South of Jianshe Road, Lubei District, Tangshan 063000, Hebei
P.R. China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Objective: The aim of this study is to investigate the clinical effect of goal-directed fluid therapy in elderly patients with radical resection of bladder cancer. Materials and Methods: Seventy-six elderly patients with radical resection of bladder cancer were selected from October 2012 to October 2014 and randomly divided into two groups, in which 38 patients received routine treatment as the control group and 38 patients received goal-directed fluid therapy based on routine treatment as the observation group. The treatment effect was compared between two groups. Results: The cardiac index, stroke volume variability, mean arterial pressure, central venous pressure, central venous oxygen saturation, oxygen supply index, oxygen consumption index, and oxygen uptake rate in observation group were distinctly higher than those in control group at T1, T2, T3, and T4 while the artery serum lactate and S100-β were apparently lower than those in control group at T1, T2, T3, and T4. The urine volume and colloidal infusion were obviously elevated when compared with those in control group at T1, T2, T3, and T4 while the crystalloid infusion volume, total liquid infusion volume, hospitalization time, and expenses were significantly less than those in control group; further, similar tendency was also found regarding the complication incidences of nausea, vomiting, or hypotension in observation group. The postoperative flatus and postoperative food-taking times were visibly earlier than those in control group (both P < 0.05). Conclusion: The goal-directed fluid therapy is beneficial for stabilization of hemodynamic status and maintenance of oxygen balance of supply and demand, and it is worthy of clinical expansion for good microcirculation perfusion, reduction in therapeutic time and expenses of patients, and less complications and superior security.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Liu TJ
    -  Zhang JC
    -  Gao XZ
    -  Tan ZB
    -  Wang JJ
    -  Zhang PP
    -  Cheng AB
    -  Zhang S
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed179    
    PDF Downloaded9    

Recommend this journal