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Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis


1 Department of Urology Surgery, -Japan Union Hospital of Jilin University, Changchun, Jilin, China
2 Department of Clinical Medicine, Bethune Medical School, Jilin University, Changchun, Jilin, China
3 Department of Tissue Bank, -Japan Union Hospital of Jilin University, Changchun, Jilin, China
4 Department of Pathology, The First Clinical Hospital of Jilin University, Changchun, Jilin, China

Correspondence Address:
Xinquan Gu,
Department of Urology Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin
China
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Source of Support: None, Conflict of Interest: None

Objective: To estimate association between androgen receptor (AR) gene polymorphisms and testicular germ cell tumor (TGCT) susceptibility. Materials and Methods: Systematic search of studies on the association between AR gene polymorphisms and TGCT susceptibility was conducted. Odds ratios and 95% confidence intervals were used to pool effect size. Results: For CAG repeat, no evidence was found for association between (>25 vs. ≤25), (>25 vs. 21–25), (<21 vs. 21–25), (others vs. 21–25), (>23 vs. ≤23), (<21 vs. ≥21), (<21 vs. ≥21)'s some subgroups and TGCT susceptibility, which showed stability. In (>24 vs. ≤24), (>24 vs. 21–24), (<21 vs. 21–24), and (others vs. 21–24) and almost all of their subgroups, increased TGCT risk was found without sensitivity analysis. For GGN, no statistical change of TGCT risk was found in (<23 vs. ≥23), (<23 vs. 23), which showed stability. For single nucleotide polymorphism (SNP) rs6152 G > A, rs1204038 G > A and rs2361634 A > G, no statistical change was found without sensitivity analysis. Conclusions: GGN repeat number <23 may not be associated with TGCTs susceptibility. However, there was insufficient data to fully confirm association in GGN repeat number >23, CAG repeat number, SNP rs6152, rs1204038, and rs2361634.


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