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The correlation of prognostic biomarkers (Ki-67, Bcl-2, HIF-1α, cyclin D1) with metabolic tumor volume measured by F-FDG PET/CT in laryngeal cancer


1 Department of Otorhinolaryngology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
2 Department of Nuclear Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
3 Department of Pathology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
4 Department of Biostatistics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey

Correspondence Address:
Aylin Eryilmaz,
Department of Otorhinolaryngology, Faculty of Medicine, Adnan Menderes University, Aydin
Turkey
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Source of Support: None, Conflict of Interest: None

Objectives: To investigate the correlation between tumor stage, Ki-67, Bcl-2, hypoxia inducible factor-1α (HIF-1α), cyclin D1 and metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUV max ) measured by 18 F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients diagnosed with laryngeal cancer. Patients and Methods: In this study, included 25 consecutive laryngeal cancer patients (2 women, 23 men) diagnosed and treated in the Otorhinolaryngology Department of our tertiary care center. All cases underwent 18 F FDG PET/CT and SUV max , mean standardized uptake value, MTV, and TLG values were calculated. Tumor staging was made and immunohistochemical staining was carried out for Ki-67, Bcl-2, HIF-1α and cyclin D1. Results: Eight (32%) patients had glottic laryngeal cancer, 6 (24%) had supraglottic laryngeal cancer and 11 (44%) had transglottic laryngeal cancer. Cyclin D1 was significantly correlated with MTV (r = 0.45, P = 0.03), TLG (r = 0.492, P = 0.01) and T-stage (r = 0.483, P = 0.02). Bcl-2 was significantly correlated with SUV max (r = -0.41, P = 0.05) and tumor stage (r = -0.442, P = 0.03). MTV and TLG are significantly correlated with nodal stage (r = 0.422, P = 0.04, r = 0.419, P = 0.04), while TLG (r = 0.403, P = 0.05) and SUV max (r = 0.440, P = 0.03) were correlated with tumor stage. Conclusion: Our results indicated that biomarkers such as cyclin D1 and Bcl-2 were correlated with measures such as MTV, TLG, and SUV in 18 F-FDG PET/CT. Integrative and combined evaluation of biomarkers and imaging data derived from 18 F-FDG PET/CT are important for staging and appropriate management of patients with laryngeal cancer.


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    -  Eryilmaz A
    -  Cengiz A
    -  Basal Y
    -  Meteoglu I
    -  Omurlu IK
    -  Yurekli Y
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