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MiR-499 rs3746444 polymorphism and hepatocellular carcinoma risk: A meta-analysis


 Department of Hepato Biliary Pancreatic Surgery, Henan Tumor Hospital (The Cancer Hospital Affiliated to Zhengzhou University), Zhengzhou 450008, Henan, China

Correspondence Address:
Feng Han,
Department of Hepato Biliary Pancreatic Surgery, Henan Tumor Hospital (The Cancer Hospital Affiliated to Zhengzhou University), No. 127, Dongming Road, Zhengzhou 450008, Henan
China
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Source of Support: None, Conflict of Interest: None

Aims: Several studies suggested that miR-499 rs3746444 polymorphism was associated with the risk of hepatocellular carcinoma (HCC). However, other studies did not confirm the result. To derive a more comprehensive estimation of the association between miR-499 rs3746444 polymorphism and HCC risk, we conducted a meta-analysis. Materials and Methods: PUBMED, COCHRANE, and WEB OF SCIENCE databases were retrieved for the association studies focused on the relationship between miR-499 rs3746444 polymorphism and the risk of HCC. The strength of the associations between miR-499 rs3746444 polymorphism and the risk of HCC was measured by odds ratios (ORs) with 95% confidence intervals (CIs). Results: A statistically significant association between miR-499 rs3746444 polymorphism and the risk of HCC was fond (OR = 1.26; 95% CI, 1.04-1.52; P = 0.02). In the subgroup analysis of race, Asian population with miR-499 rs3746444 polymorphism showed increased HCC risk (OR = 1.29; 95% CI, 1.03-1.62; P = 0.03). In the subgroup analysis of hepatitis virus status, patients with HBV and miR-499 rs3746444 polymorphism showed increased HCC risk (OR = 1.38; 95% CI, 1.17-1.64; P = 0.0002). In the subgroup analysis of source of control, both hospital- and population-based studies found significant results (OR = 1.46; 95% CI, 1.12-1.90; P = 0.005; OR = 1.19; 95% CI, 1.01-1.40; P = 0.04). Conclusions: This meta-analysis suggested that mir-499 rs3746444 polymorphism was associated with an increased HCC risk.


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    -  Qiu D
    -  Han F
    -  Zhuang H
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