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Serum B7 homologous body 4 for the diagnosis of ovarian cancer in Chinese Han women: A meta-analysis

1 Department of Obstetrics and Gynecology, West Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China
2 Department of Medical Informatics, West School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China

Correspondence Address:
Mingrong Xi,
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, Sichuan 610041
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Source of Support: None, Conflict of Interest: None

Objective: The aim of this study is to investigate the clinical value of serum B7 homologous body 4 (B7-H4) protein detection for the diagnosis of ovarian cancer (OC) in Chinese Han women by pooling published data. Methods: A systematic literature search was conducted in Cochrane Library, PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure databases. The bivariate model was utilized to calculate the pooled estimates. Publication bias was assessed by using funnel plots and Deek's test. Results: After the review, ten publications were found to meet our inclusion criteria. The overall diagnostic sensitivity and specificity of B7-H4 in OC were 0.782. (95% confidence interval. [CI]: 0.732-0.825) and 0.870. (95% CI: 0.804-0.916), respectively. The area under summary receiver operating characteristic curves was 0.86. (95% CI: 0.83-0.89). No significant publication bias was observed in the included studies. Conclusion: Serum B7-H4 detection, either alone or in combination with carbohydrate antigen 125, has an acceptable value in the diagnosis of OC.

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